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The beginnings of CDKL5
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Roadmap to a Cure


 

Estimated Time Lines and Costs

Mouse Models
  • Need 3-4 mouse models with reproducibility
  • 1-1.5 yr/ mouse
  • $100,000/ mouse
  • Characterization: $50,000/mouse
iPS Cells
  • Need 3-4 cell lines with reproducibility
  • Correlation to Mouse lines helpful
  • $100,000 to $300,000
  • 6-8 months per line
Protein Target Identification
  • Proteomics $50,000
  • Mass spectrometry $30,000
  • 1-2 years
Drug Discovery, Screening and Development
  • $2.5 million
  • 2-3 years
Phase I (Drug) Clinical Trial
  • $250,000
  • 2 years
Phase II (Pilot) Clinical Trial
  • $1.8 million
  • 1.5 years
Phase III Clinical Trial
  • $8 million
  • 3 years
DATA BASE
  • Ongoing
  • Critical for determining Therapeutic Endpoints for Trials
  • $75,000

 

Roadmap to a Cure

© 2012