Request for Proposals

IFCR Grant program

Request For Proposals – 2018 Priority areas

1. Research dedicated to furthering the understanding of CDKL5 function to
inform the development of targeted, novel therapies.

2. Transformative research to enhance our understanding of the cellular,
molecular, genetic and systems-level mechanisms contributing to the
pathogenesis of CDKL5 deficiency disorder, facilitating the continued
investigation of disease-modifying strategies.

3. Development of high-throughput techniques (and relevant animal/cellular
models) to assess the potential efficacy of therapeutic interventions against
phenotypic deficits of CDKL5 deficiency disorder.

4. Translational and clinical research that will facilitate elevated understanding
of the natural history of CDKL5 deficiency disorder as it relates to symptom
progression (including but not limited to seizures and cognitive delay),
pharmacosensitivity, and response to behavioral/supportive therapies.

Eligibility

IFCR research awards are available to both established and junior investigators. All
materials must be submitted in English. IFCR encourages research projects that are
collaborative and with a multidisciplinary approach.

Budget

Funding requests may include salary support for the PI, technical staff and/or
collaborators; supplies, animal costs, etc. Indirect costs are not supported. IFCR
requires a detailed budget submitted with final grant application. Budgets are
flexible based on the needs of the work proposed and the potential teams involved.

2018 Funding Cycle Details

In 2018, the IFCR will issue a rolling request for proposals for the Seed Grants, the
Junior Investigator Grants, and the Clinical Research Fellowship awards. The 2019
funding cycle timeline to be announced at a future date.

LOI Guidelines

Below are instructions for the required sections of the LOI, which together can be no
longer than two (2) pages in length. The LOI should clearly and succinctly outline
the hypotheses under investigation, the specific aims, and provide a brief
description of the anticipated deliverables if successful.

1. Project Title
2. Participants
3. Project Goals
4. Responsiveness to 2018 IFCR priority areas
5. Brief Background
6. Specific Aims
7. Deliverables (including anticipated future funding based on this work)
8. Requested Resources
9. Current and Pending Support

Submit your Letter of Intent or any questions to:

Heidi Grabenstatter, PhD

Email: hgrabenstatter@cdkl5.com